The Puerto Rico IDeA Network of Biomedical Research Excellence hosted the 2021 Southeast Regional IDeA Conference in San Juan, Puerto Rico, on November 12-14, 2021. The Regional Conference served as an important platform for faculty, postdoctoral, and student scientists of the Southeastern IDeA States and Puerto Rico to discuss science, administrative policy, and best practices in a cordial and interactive scholarly environment. The Hispanic Alliance for Clinical & Translational Research in Puerto Rico (Alliance) participated in different panels as presenters and in the poster sessions during the Conference. This activity was very productive and successful.